Articles Tagged With:
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Small World, Big Data: International Research Collaborations
The National Institutes of Health has encouraged international collaboration in the Human Genome Project and other precision medicine research.
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Researcher: Measure the Quality and Efficacy of IRBs
While it is intuitive that IRB oversight effectively protects human research subjects from ethical breaches and other risks, there is surprisingly little data on the quality and performance of review boards.
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NIH Marshalling Data Defenses for All of Us Project
In a disarmingly frank lecture in an ethics training course at the National Institutes of Health, a leader of the landmark All of Us project shared some of the concerns that come with the immense responsibility of collecting data on 1 million people.
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New Common Rule Suggests Changes for Informed Consent Documents
IRBs often spend too much time wordsmithing informed consent forms and not enough time on the big issue of comprehension, one IRB director says.
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Research Offers Clues on How to Improve Informed Consent
Deciding to make informed consent as comprehensible as possible is the easy part. What is not easy is determining how to accomplish this goal.
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Beware of Good and Bad News About the New Common Rule
The revised Common Rule changes will go into effect on Jan. 21, 2019, but it is quite likely IRBs will be adjusting their processes without all of the federal guidance they need.
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A Review of Updated Guidelines Regarding Bradycardia and Cardiac Conduction Delay
The American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society have established updated guidelines on the evaluation and management of patients with bradycardia and conduction delays. Many key elements remain largely unchanged from prior guideline recommendations on pacemakers published in 2008 and 2012, but there also are important new definitions, recommendations, and areas of emphasis.
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Early Identification of Cardiac Amyloidosis in Carpal Tunnel Surgery Patients
In a cohort of older patients undergoing carpal tunnel release surgery, an analysis of tenosynovial tissue revealed amyloid deposits in 10% of patients. This development may facilitate early diagnosis of cardiac amyloidosis.
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Mitral Annulus Disjunction and Ventricular Arrhythmias
A patient cohort with mitral annular disjunction (MAD) identified by echo was characterized clinically and by MRI. Ventricular arrhythmias were common in MAD patients and related to the degree of MAD and papillary muscle fibrosis by MRI but not the presence of mitral valve prolapse.
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Detection of Prosthetic Heart Valve Endocarditis
A multicenter, retrospective, observational study of patients undergoing 18F-fluorodeoxyglucose PET/CT for prosthetic valve endocarditis or other indications showed that if certain obvious confounders are excluded, this imaging technique offers a high degree of accuracy for diagnosing prosthetic valve endocarditis, especially if performed early in the course of the disease.